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ISMP Canada has informed Health Canada about the Canadian report received and the information highlighted in this articleAstellas Pharma Canada Incthe manufacturer of both Prograf and Advagrafis also aware of these issues and is supportive of ISMP Canada sharing this informationAstellas Pharma Canada Inc is working to implement various measures to reduce the potential for mix-ups between Prograf and Advagraf.
Anaphylactic reactions have occurred with injectables containing castor oil derivativessuch as Prograf injectionsee WARNINGS AND PRECAUTIONS
The relative risks of toxicity and efficacy failure are related to tacrolimus whole blood trough concentrationsThereforemonitoring of whole blood trough concentrations is recommended to assist in the clinical evaluation of toxicity and efficacy failure.
This is not a complete list of possible side effectsIf you notice other effects not listed abovecontact your doctor or pharmacist.
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do not change the way you take this medicine without telling your transplant team, since this could change the amount of protection you get from prograf.